MPA
Description
MPA, or 1-(thiophen-2-yl)-2-methylaminopropane, is a research chemical from the phenethylamine family. It is similar in structure to other phenethylamine drugs like amphetamine and methamphetamine, and is often used as a study aid or as a recreational drug. MPA is known for its stimulating effects, and is often compared to Ritalin or Adderall.
Physical Effects
MPA acts as a dopamine-norepinephrine reuptake inhibitor (NDRI), which leads to an increase in the levels of dopamine and norepinephrine in the brain. This, in turn, produces a stimulating effect that can help users feel more alert and focused. MPA is typically found in the form of a white powder, and is often taken orally or nasally.
Chemistry
MPA is a synthetic compound with the chemical formula C10H14NS. It has a molar mass of 178.29 g/mol and a melting point of 187-189 °C. MPA is often synthesized from thiophene and 2-bromo-1-phenylpropane using reductive amination.
Dosing
The appropriate dosage of MPA depends on several factors, including the user’s age, weight, and tolerance to the drug. It is recommended that first-time users start with a small dose of around 20-30mg, and wait at least 2-3 hours before taking another dose. The effects of MPA can last for 4-6 hours.
Effects
MPA is known for its stimulating effects. Users may experience increased focus, alertness, and wakefulness. However, it can also cause negative effects such as increased heart rate, anxiety, and insomnia. Long-term use of MPA can lead to addiction and other health problems, so it is important to use this drug responsibly and in moderation.
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Methiopropamine (also known as MPA) is a stimulant substance of the thiophene class. It is a ring-based structural analogue of methamphetamine.
Methiopropamine was first synthesized in 1942. It appeared for public sale in the U.K. in December 2010 as a research chemical or legal high, recently branded as “Blow”.
Subjective effects are reportedly similar to those of classical stimulants and includes stimulation, focus enhancement, motivation enhancement, increased libido, appetite suppression, and euphoria. However, it is generally considered to be as euphoric or recreational as classical stimulants. It is occasionally reported to be used as a study aid.
Limited data exists about the pharmacology and toxicity of methiopropamine in humans, and it has only a short history of human use. It is highly advised to use harm reduction practices if using this substance.
Chemistry
Methiopropamine, or 1-(thiophen-2-yl)-2-methylaminopropane, is a synthetic molecule of the thiophene class. It is a structural analogue to methamphetamine. It contains a thiophene ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Methiopropamine contains an additional methyl substitution at RN (similarly to MDMA and methamphetamine). Although methiopropamine is analogous to methamphetamine, it is neither an amphetamine nor a phenethylamine as methiopropamine contains a thiophene ring instead of a benzene ring. Thiophene is a five-membered aromatic ring with a sulphur constituent.
Pharmacology
Methiopropamine functions as a selective norepinephrine-dopamine releasing agent. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects. It is approximately one third as potent as dextroamphetamine as a norepinephrine reuptake inhibitor and one fifth as much as a dopamine reuptake inhibitor. It displays negligible activity as a serotonin reuptake inhibitor.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation – In terms of its effects on the physical energy levels of the user, methiopropamine is usually considered to be mildly to moderately energetic and stimulating in a fashion that is considerably weaker in comparison to that of traditional recreational stimulants such as amphetamine, MDMA or cocaine. This encourages physical activities such as performing chores, repetitive tasks which would otherwise be boring and strenuous physical activities.
Spontaneous tactile sensations – The “body high” of methiopropamine can be described as an intense euphoric, sharp and all-encompassing tingling sensation that remains present through the duration of the experience.Increased heart rate – In comparison to other stimulants such as amphetamine or cocaine, methiopropamine only has a mild effect on one’s heart rate.
Appetite suppression The above components are also accompanied by a suppression of appetite which is usually much less intense in strength in comparison to the appetite suppression experienced with amphetamine or methamphetamine.
Increased perspiration
Increased libido
Temperature regulation suppression
Teeth grinding – This component can be considered to be less intense when compared with that of MDMA.
Cognitive effects
Focus enhancement – This component is most effective at low to moderate doses as anything higher will usually impair concentration.
Cognitive euphoria – This component is much less intense than the euphoria experienced with other stimulants such as amphetamine, cocaine, or methamphetamine.
Wakefulness
Thought acceleration
Thought organization
Analysis enhancement
Motivation enhancement
Compulsive redosing
Increased music appreciation
More Info: https://psychonautwiki.org/wiki/Methiopropamine
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